The fates of three strangers collide when Tony (Benicio Del Toro), an ex-convict and born-again Christian, accidentally kills aman and his two daughters. As Tony struggles to reconcile his fear of jail with a tenuous faith, the widowed Christina (Naomi Watts) descends into a dangerous cycle of grief, rage, and drug abuse. Paul (Sean Penn) is a mathematician slowly dying of heartdisease, who after receiving a transplant finds himself healthy but trapped inside a withering marriage.

As in the critically acclaimed Amores Perros--with whose director Arriaga is once again paired--the unique and individual obsessions ofeach character become helplessly intertwined while the story moves toward an inevitable conclusion ripe with revenge and redemption. In addition to the script, this volume fully documents the production of the film via extensive original interviews with the filmmakers and numerous photographs.