Stereoselective Synthesis of Biologically Active Novel Heterocycles Sesha Sridevi Alluri and A. K. Ganguly

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Sesha Sridevi Alluri and A. K. Ganguly - «Stereoselective Synthesis of Biologically Active Novel Heterocycles»

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Many of the drugs in human medicine are chiral because they bind to enzymes and receptors to elicit biological activity. Both enzymes and receptors are chiral and therefore in a chiral drug molecule one of the enantiomer is more active than the other. Most of the drugs are also heterocyclic in nature. In the present study we have conceived ideas of what heterocycles might show activity against a particular disease based on their bindings at enzyme or receptor level and investigated the role of chirality in these molecules. Novel synthetic methodologies were developed for the enantioselective synthesis of these heterocycles possessing chiral centers and we believe these synthetic methodologies will be useful for the synthesis of other drugs. Using the above general concepts we have synthesized novel enantiomerically pure chiral heterocylces such as 5-aryl oxindoles, which have shown potent activity as progesterone receptor antagonists, spiro-oxindoles, for possible use as cancer... Это и многое другое вы найдете в книге Stereoselective Synthesis of Biologically Active Novel Heterocycles (Sesha Sridevi Alluri and A. K. Ganguly)

Полное название книги Sesha Sridevi Alluri and A. K. Ganguly Stereoselective Synthesis of Biologically Active Novel Heterocycles
Автор Sesha Sridevi Alluri and A. K. Ganguly
Ключевые слова органическая химия, химические науки
Категории Образование и наука, Химия
ISBN 9783659260476
Издательство
Год 2012
Название транслитом stereoselective-synthesis-of-biologically-active-novel-heterocycles-sesha-sridevi-alluri-and-a-k-ganguly
Название с ошибочной раскладкой stereoselective synthesis of biologically active novel heterocycles sesha sridevi alluri and a. k. ganguly