Hepatitis B virus and hepatitis C virus may be involved in hepatocarcinogenesis in patients with HCC. These viral infections may be responsible, at least in a part, for the mutational change in the p53 gene and may affect the expression of the Bcl-2 protein in HCC patients. p53 and Bcl-2 proteins overexpression was detected in serum and tissues in HCC patients positive for hepatitis B or C or both and this overexpression was more frequently associated with HBV infection than HCV infection. Это и многое другое вы найдете в книге Apoptosis related proteins p53 and Bcl-2 in hepatocellular carcinoma (Entsar Saad,El-Shahat Toson and Hoda El-Emshaty)
Apoptosis related proteins p53 and Bcl-2 in hepatocellular carcinoma Entsar Saad, El-Shahat Toson and Hoda El-Emshaty (книга)
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