Excerpt from The Practical Medicine Series, Vol. 7: Comprising Eight Volume on the Years"s Progress in Medicine and Surgery
Protein Sensitization in Production of Skin Disease. After a critical review of the literature, Towle says that protein sensitization is now an accepted fact. The theories as to its meaning and its mechanism differ and much that has been published concerning the process lacks confirmation. There is still much work to do in allied fields, such as the diatheses and the intoxications, before full use can be made of the new cult. In the meantime, while accepting the principles of the cutaneous food tests, interpretation must await fuller, better defined understanding of the process of protein sensitization before it can attain its greatest efficiency.
Protein Sensitization in Skin Diseases. A critical discussion of the various theories, a review of the literature and the results of the tests applied in a series of cases appear in an article by Highman and Michael.
Of the sixty-three positive reactions, thirty-seven were to vegetable and twenty-six to animal proteins. Reactions to more than one protein occurred in eleven of the twelve cases tested. Reactions to both vegetable and animal proteins occurred in ten cases. In one case only buckwheat was tried. Suprarenal extract was of benefit in eight cases; it was not employed in five and caused collapse in one.
The authors believe that urticaria and allied conditions, notably angioneurotic edema, are anaphylactic manifestations. Moreover, they believe the positive protein tests prove them to be anaphylactic. They believe that the protein food tests are of great value inasmuch as the tests indicate sensitization to a definite protein which, in treatment, is to be removed from the diet.
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