Excerpt from The Practitioner, Vol. 32: A Journal of Therapeutics and Public Health; January to June
Christison, Gregory, Elliotson, Copland, &c., brought observations in support of Bright"s discovery. Rayer studied the pathological anatomy of albuminous nephritis more precisely, and in his work on diseases of the kidney he describes six forms of nephritis, the two first of which belong to the class of transient albuminous nephritis, and the last to that of permanent albuminous nephritis. Rayer considers them to be different stages of the same morbid processes. In 1838 Martin Solon reduced the number of anatomical forms of the disease to four.
But already the microscopical study of lesions of the kidney and of urinary sediments had commenced. A. Becquerel noticed hypertrophy of the Malpighian corpuscles in 1841, and Fluge, Henle, Vogel, and Canstatt made some unimportant microscopical observations.
William T. Gairdner and George Johnson utilised the discoveries of Bowman regarding the intimate structure of the kidney in their study of the pathological anatomy of the organ.
Virchow, Reinhardt, and Frerichs, took up the question in turn. For a long time the treatise of Frerichs remained the best on the subject. He distinguished three stages in albuminous nephritis: -
(1) The stage of hyperaemia and of commencing exudation.
(2) The stage of exudation and of metamorphosis of the exuded products.
(3) The stage of atrophic regression.
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