Excerpt from The Principles of Immunology
This book has been prepared in the hope that a concise statement of the facts and more important hypotheses concerning resistance to infection may serve to provide a clear understanding of a subject of the utmost importance in modern diagnosis and treatment. Designed primarily for students of medicine and for those practitioners whose duties have made it impossible to digest a large mass of publications on the subject, the scope of the book is restricted to fundamental principles. The plan throughout is to present on an experimental basis the demonstrated facts and to supplement these with brief discussions of the practical and theoretical bearing of the phenomena upon resistance and disease in man. A few illustrations have been inserted, but it must be recognized that technical details can only be fully comprehended on the basis of actual work with the methods. The usual diagrams of the side-chain theory have been omitted because of the belief that they serve to confuse rather than clarify the conception of processes whose fundamental basis lies in the field of physical chemistry. Certain material concerning the practical application of immunology to the prevention and cure of disease has been collected in three appendices. These have been added in order to explain the basis of the practical methods rather than as an exact guide in their application.
Knowledge progresses from the known to the unknown, from the simple to the complex, and if the brevity of the book serves to implant essentials in such a way that the reader not only grasps the facts, but finds himself stimulated to seek further information and discussion in more comprehensive works, the most compelling aim of this book will have been achieved. For this purpose books which we have used with considerable freedom arc recommended: Zinsser, "Infection and Resistance"; Wells, "Chemical Pathology"; Kolmer, "Infection, Immunity, and Specific Therapy"; Kraus and Levaditi, "Handbuch der Technik und Methodik der Immunitatsforschung"; Muir, "Studies on Immunity"; Kolle and Wassermann, "Handbuch der pathogenen Mikroorganismen"; Metchnikoff, "Immunity in Infective Diseases"; Bordet, "Traite de l'Immunite dans les Maladies Infectieuses"; Besredka, "Anaphylaxis and Antianaphylaxis"; Bordet and Gay, "Studies in Immunity"; Gay, "Typhoid Fever"; Browning, "Applied Bacteriology"; Craig, "The Wassermann Test"; Noguchi, "Serum Diagnosis of Syphilis"; Zinsser, Hopkins, and Ottenberg, "Laboratory Course in Serum Study."
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