Excerpt from Studies From the Biological Laboratory, Vol. 4
Since Schmidt-Mnlheim"s discovery of the fact that peptone injected into the circulation of a living animal would prevent the coagulation of its blood, if drawn shortly after the injection, various hypotheses have been suggested as to what the nature of the action was. Schmidt-Mulheim himself thought that peptone did not act directly upon the substances taking part in the formation of fibrin, but that It caused something to be used up, which must be present in order that coagulation might take place. He found that the effect of peptone in preventing coagulation passed off in a comparatively short time, but that the blood still was not restored to its former condition, since a second injection of peptone had no effect until 24 hours had elapsed. Peptone disappears from the blood very quickly, and, according to his observations, none is found in the urine. He found that peptone blood was not incapable of coagulating, for if it was simply allowed to stand until putrefactive changes ban, a firm clot was produced. He concludes that the peptone in some way prevented the formation of fibrin ferment.
Fano repeated and extended this work. He found that 0.3 gr. of peptone to each kilo, of body weight was the most favorable quantity to inject, when all was injected at once. A much larger amount than this might be injected at intervals without affecting coagulation in the least. This was true at any rate for dogs. Rabbits, on the other hand, were not in the least affected by peptone in any quantity; and to anticipate a little, I may here say that have found that cats likewise are not affected. Fano explained the disappearance of peptone by supposing that it entered into a combination with some element of the blood and kept it from taking part in coagulation, at the same time losing its own identity.
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