Is Aurora Kinase C a Proto-oncogene? Jabbar Khan and Marie Berengere Troadec

Aurora kinases are the key regulators of cell cycle progression. Aurora-A and Aurora-B, expressed in somatic cells and are involved mainly in mitosis. Aurora-C is mainly expressed during gametomatogenesis and is involved in meiosis. Aurora-C is hardly detectable in normal somatic cells. The kinases are overexpressed in many cancer lines. Aurora-A possesses an oncogenic activity while Aurora-B does not. We investigated whether Aurora-C possesses such an oncogenic activity. We report that overexpression of Aurora-C induces abnormal centrosome amplification and multinucleation. The stable NIH3T3 cell clones overexpressing active Aurora-C formed foci of colonies when grown on soft agar, indicating that a gain of Aurora-C activity is sufficient to transform cells. We also reported that stable cell lines overexpressing Aurora-C induced tumour formation when injected into nude mice and abnormal mitosis along cell cycle, demonstrating the oncogenic activity of active Aurora kinase C.... Это и многое другое вы найдете в книге Is Aurora Kinase C a Proto-oncogene? (Jabbar Khan and Marie Berengere Troadec)