Excerpt from Chemical Pathology: Being a Discussion of General Pathology From the Standpoint of the Chemical Processes Involved
The rapid growth of interest in the chemical problems of medical and biological science is shown by the great increase in the amount of material which must be included in each succeeding edition. Although this latest edition has been subjected to extensive revision and many minor alterations, yet the general plan has not been changed. The rapidly growing information concerning the nutritional factors that are essential to growth and repair, and without which serious "Deficiency Diseases" may arise, has necessitated the introduction of a new chapter to cover this subject, the importance of which has been accentuated by the war and its sequels. The growing bulk of material on the Reactions of Immunity required a rearrangement of this material, so that a separate chapter on Anaphylaxis and Allergy has been provided, for purposes of convenience. Numerous sections have been entirely rewritten, and few pages have not required revision or addition.
In order to prevent the increasing material that must be included from resulting in too cumbersome a volume, much more of the matter is printed in smaller type. It is hoped that this arrangement will achieve its aim without serious reduction in facility of use. The author recognizes fully that it would be easily possible to report the existing state of knowledge on the topics covered in "Chemical Pathology" in a much briefer space, if only completely established evidence were included. With the object of serving as a guide to investigators, and with the hope of stimulating further investigations, much more than this minimal amount of existing evidence is included. It is also recognized that the brief discussion of the elementary principles of physical chemistry and the fundamentals of the physics and chemistry of living cells, which constitutes the introductory chapter, may be out of place in a work on Pathology, and the elimination of this chapter has been seriously considered. Repeated assurances of the usefulness of such a presentation, however, have resulted in its retention, at least for the present.
As with all previous editions, my indebtedness must be acknowledged to numerous colleagues who have kindly read over the sections of this book which most closely concern their own fields, and especially to the members of my Department and of the Sprague Institute who have made many useful suggestions. The chapter on Diabetes is, as before, contributed by Dr. R. T. Woodyatt, Director of the Laboratory of Clinical Research of the Otho S. A. Sprague Memorial Institute.
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