Excerpt from General Chemistry of the Enzymes
As the title of this book indicates, the author has attempted to review the more important facts of enzymology from a general standpoint and to fit them, so far as is possible, into their proper places in the fabric of general and physical chemistry. The aim has not been to give a complete synopsis of our knowledge of the enzymes, for already several such summaries are available.
It may perhaps be asked: Is the time yet ripe for giving a representation of the physical chemistry of the enzymes? The author feels that this question must be answered in the affirmative, although it is evident that extensive regions and important problems in the subject are still entirely untouched. The period during which the marshalling of facts was the most essential task was followed by one in which it was sought to harmonize the somewhat crude and imperfect experimental data with the laws of theoretical chemistry. The deviations from theory seemed to be wide and the peculiarities of enzymic reactions numerous. Only in the most recent times has the need for experimental revision of the quantitative data made itself felt. Improvements have been effected in the practical methods, while the factors participating in the reactions have become more clearly understood and are hence more fully taken into account. It is now being found that the results obtained from these more exact and comprehensive investigations correspond more closely with those required to satisfy physico-chemical theories. At the stage which has thus been reached in the development of enzymology a review such as that now published does seem to be justified.
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