Excerpt from The Chemical Basis of Pharmacology: An Introduction to Pharmacodynamics Based on the Study of the Carbon Compounds
'Did we know the mechanical affections of the particles of rhubarb, hemlock, opium, and a man, as a watchmaker does those of a watch, whereby it performs its operations, and of a file, which by rubbing on them will alter the figure of any of the wheels, we should be able to tell beforehand that rhubarb will purge, hemlock kill, and opium make a man sleep; as well as a watchmaker can that a little piece of paper laid on the balance will keep the watch from going till it be removed; or that, some small part of it being rubbed by a file, the machine would quite lose its motion and the watch go no more.'
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